Table 2.
The 2K to 1K transition is associated with reduced podocyte nuclear density due to glomerular enlargement with compensatory podocyte hypertrophy
| Parameter | At Implantation | 3 Mo Later | Change (%) | P Value |
|---|---|---|---|---|
| Tuft number per biopsy | 23.2±10.7 | 20.3±8.3 | 0.30 | |
| Glomerular volume (μm3×106) | 2.4±0.7 | 2.9±1.0 | +21 | 0.02 |
| Podocytes per glomerulus (n) | 492±117 | 475±129 | −4 | 0.50 |
| Glomerular volume per podocyte (μm3×106) | 5.1±1.5 | 6.2±2.3 | +23 | 0.02 |
| Podocyte nuclear density (n per 106 μm3) | 216±69 | 172±46 | −20 | <0.01 |
| Glepp1 area density (%) | 43.5±5.0 | 41.3±6.0 | −5 | 0.15 |
| Glepp1-positive glomerular volume (μm3×106) | 1.1±0.3 | 1.2±0.3 | +10 | 0.18 |
| Glepp1-negative glomerular volume (μm3×106) | 1.4±1.4 | 1.7±0.8 | +24 | 0.02 |
| Mean podocyte volume (μm3×103) | 2.2±0.7 | 2.6±1.0 | +19 | 0.03 |
| Mean nuclear caliper diameter (μm) | 7.1±0.7 | 7.4±0.8 | +4 | 0.06 |
Morphometric parameters are shown for paired sample analysis in which each implantation (time 0) biopsy was paired with its 3-month biopsy from the same kidney (n=18 pairs). For unpaired analysis shown in Table 4, additional samples were included that did not have pairs. Statistical and fold comparisons are shown.