Table 1.
Predonation demographic, physiologic, and morphometric data
| Parameter | Normotensive Youthful Donors (n=24) | Normotensive Aging Donors (n=17) | Hypertensive Aging Donors (n=10) |
|---|---|---|---|
| Women (%) | 11 (46) | 8 (47) | 6 (60) |
| Age (yr) | 33.5 (29–42) | 56 (55–59.6) | 58 (55.75–61.5) |
| MAP (mmHg) | 88 (84–92) | 93 (83–101) | 97 (91–109) |
| Iothalamate GFR (ml/min per 1.73 m2) | 115±18 | 95±16a | 89±12a |
| RPF (ml/min per 1.73 m2) | 574±110 | 466±103a | 448±52a |
| Filtration fraction | 0.20±0.03 | 0.21±0.02 | 0.2±0.03 |
| πA (mmHg) | 26.7±2.7 | 26.5±1.9 | 24.8±1.9 |
| Whole-kidney Kf (ml/[min/mmHg]) | 11.9 (10.5–14.9) | 9.8 (7.3–13) | 8 (6.1–8.8)a |
| Global sclerosis (%) | 0 (0–3) | 4.3 (0–7.5) | 5.6 (0–10.5) |
| Glomerular volume (µm3×106) | 2.71±0.69 | 2.67±0.76 | 3.03±1.03 |
| Basement membrane thickness (nm) | 342 (318–378) | 328 (291–357) | 331 (314–391) |
| Filtration slit frequency (per mm) | 1650±192 | 1642±143 | 1553±159 |
| Hydraulic permeability (m/s per Pa×10−9) | 2.7±0.3 | 2.7±0.3 | 2.5±0.2 |
| SNKf (nl/[min/mmHg]) | 9.27 (7.63–11.45) | 10.94 (7.8–11.9) | 9.21 (6.99–11.74) |
| Renocortical volume (cm3) | 115±21b | 105±15c | 98±26 |
a
P<0.01 versus normotensive youthful donors.
b
n=23.
c
n=15.