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. 2015 May 28;5:9996. doi: 10.1038/srep09996

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Copyright © 2015, Macmillan Publishers Limited

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Sampling distribution of the sample mean pairwise F_ST between populations. Average F_ST value of genes associated with resistance/susceptibility to malaria (♦) is significantly lower than the mean F_ST score of the sampling distribution in all pairwise comparisons. COP = Copts; NOR = Beja, Ethiopians, Arabs and Nubians; SOU = Darfurians, Nuba and Nilotes; FUL = Fulani. The sampling distribution is drawn from the mean F_ST value of subsets of randomly selected genic SNPs with a sample size equal to the number of common SNPs between populations in the selected genes (n) and with similar MAF (10,000 permutations).