Table 6.
Genes with altered expression after in vivo exposure to high blood glucose
| Downregulated genes after hyperglycemia | |||||||
|---|---|---|---|---|---|---|---|
| Gene name | Symbol | Controls (n = 3) | MetS (n = 4) | T2DM (n = 6) | |||
| FC | q-value | FC | q-value | FC | q-value | ||
| Granzyme B | GZMB | 0.42 | 0.00 | 0.71 | 0.00 | 0.97 | 98.95 |
| Granulysin | GNLY | 0.47 | 0.00 | 0.92 | 88.23 | 1.07 | 96.96 |
| Perforin 1 | PRF1 | 0.48 | 0.00 | 0.77 | 75.30 | 0.96 | 98.64 |
| Fibroblast growth factor binding protein 2 | FGFBP2 | 0.50 | 0.00 | 1.00 | 99.70 | 1.17 | 96.96 |
| Chloride intracellular channel 3 | CLIC3 | 0.56 | 0.00 | 0.95 | 93.51 | 1.03 | 98.21 |
| Killer cell immunoglobulinlike receptor, two domains, long cytoplasmic tail, 4 | KIR2DL4 | 0.62 | 0.00 | 0.89 | 65.06 | 1.05 | 96.96 |
| Chromosome 1 open reading frame 162 | C1orf162 | 0.66 | 0.00 | 0.75 | 0.00 | 0.90 | 81.90 |
| Cystatin F (leukocystatin) | CST7 | 0.67 | 0.00 | 1.01 | 97.65 | 1.03 | 98.21 |
| Galectin 1 | LGALS1 | 0.68 | 0.00 | 0.97 | 98.10 | 0.97 | 98.72 |
| FK506 binding protein 5 | FKBP5 | 0.68 | 9.78 | 0.51 | 0.00 | 0.71 | 37.55 |
| TSC22 domain family, member 3 | TSC22D3 | 0.73 | 10.48 | 0.70 | 0.00 | 0.64 | 0.00 |
| Dual specificity phosphatase 1 | DUSP1 | 1.02 | 96.30 | 0.71 | 70.35 | 0.69 | 0.00 |
| Myeloid cell leukemia sequence 1 (BCL2related) | MCL1 | 1.00 | 97.20 | 0.89 | 67.05 | 0.81 | 0.00 |
| Upregulated genes after hyperglycemia | |||||||
| Interleukin 8 | IL8 | 1.24 | 66.30 | 1.44 | 0.00 | 1.46 | 22.49 |
| HIV1 Tat specific factor 1 pseudogene | LOC401233 | 1.18 | 67.90 | 1.24 | 0.00 | 1.07 | 96.96 |
FC indicates fold change compare to baseline levels. q-value indicates the false discovery rate (%). Significant changes are indicated in bold (q < 5 %). Gene symbols indicated in bold are cytotoxicity related, and visualized in Fig. 4