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. Author manuscript; available in PMC: 2015 May 28.
Published in final edited form as: Eur Cytokine Netw. 2014 Oct-Dec;25(4):69–76. doi: 10.1684/ecn.2015.0359

Figure 3. IL-10 pretreatment modulates post-I/R cytokine expression.

Figure 3

Mice were evaluated for hepatic cytokines IL-1β, TNF-α, and IL-10 mRNA at six hrs post-reperfusion by qRT-PCR. IL-1β mRNA levels were significantly upregulated in the livers of ob/ob (Ob) animals as compared to lean control (Wt) and IL-10-pretreated ob/ob (Ob IL-10) animals. No significant changes in TNF-α expression were noted. Elevation of IL-10 transcripts in livers of Ob animals after I/R was significantly less than that seen in Wt and Ob IL-10 mice. Fold-change is a comparison to mice not subjected to I/R. Means with different lettered subscripts within each group are significantly different from each other (a is significantly different from b), p<0.05. Data are expressed as mean ± SD; n = 3–6.