Skip to main content
. Author manuscript; available in PMC: 2015 May 28.
Published in final edited form as: Proteins. 2008 Dec;73(4):1021–1036. doi: 10.1002/prot.22134

Figure 2.

Figure 2

Schematic illustration of the overall elongation mechanism. (A) Pretranslocated state with fingers domain open, and the 3′-end of RNA occupying NTP binding site. (B) Posttranslocated state with fingers domain open, and the 3′-end of RNA cleared of binding site. (B′ ) Hypertranslocated state with fingers domain open, and the 3′-end of RNA two steps upstream of binding site. (C) Substrate complex with bound NTP and fingers domain closed. (D) Product complex with NMP incorporated into 3′-end of RNA and PPi bound nearby. The current work focuses on the transitions between the states (A) and (B). [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]