Comparison 2. IPT in high versus low endemic areas.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All cause mortality plus hospital admissions at 6 months	3	3160	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.71, 1.13]
1.1 High endemicity	2	1960	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.71, 1.19]
1.2 Low endemicity	1	1200	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.43, 1.44]
2 Children with anaemia at 12 weeks	4	2237	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.88, 1.07]
2.1 High endemicity	2	709	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.90, 1.15]
2.2 Low endemicity	2	1528	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.74, 1.07]
3 Mean change in Hb (baseline to 12 weeks)	4	1672	Mean Difference (IV, Fixed, 95% CI)	0.32 [0.19, 0.45]
3.1 High endemicity	2	641	Mean Difference (IV, Fixed, 95% CI)	0.35 [0.17, 0.53]
3.2 Low endemicity	2	1031	Mean Difference (IV, Fixed, 95% CI)	0.29 [0.10, 0.48]
4 Mean Hb at 12 weeks	4	1672	Mean Difference (IV, Random, 95% CI)	0.35 [0.06, 0.64]
4.1 High endemicity	2	641	Mean Difference (IV, Random, 95% CI)	0.44 [‐0.03, 0.91]
4.2 Low endemicity	2	1031	Mean Difference (IV, Random, 95% CI)	0.20 [0.01, 0.40]