Table 2.
Reproductive surgery and risk of incident cancer in the Black Women's Health Study, 1995–2011
| No hysterectomy | Hysterectomy alone | With bilateral oophorectomy | |
|---|---|---|---|
| Breast cancer | |||
| Cases/person-years | 808/326,182 | 180/56,178 | 183/69,841 |
| Age-adjusted HR | 1.00 (Ref.) | 1.08 (0.92–1.28) | 0.80 (0.67–0.94) |
| Multivariable HR | 1.00 (Ref.) | 1.11 (0.93–1.31) | 0.82 (0.67–0.99) |
| ER+ breast cancer | |||
| Cases/person-years | 428/325,753 | 96/56,079 | 88/69,740 |
| Age-adjusted HR | 1.00 (Ref.) | 1.06 (0.84–1.33) | 0.69 (0.54–0.87) |
| Multivariable HR | 1.00 (Ref.) | 1.04 (0.82–1.31) | 0.65 (0.50–0.86) |
| ER– breast cancer | |||
| Cases/person-years | 236/325,575 | 48/56,037 | 60/69,705 |
| Age-adjusted HR | 1.00 (Ref.) | 1.03 (0.75–1.41) | 0.96 (0.71–1.29) |
| Multivariable HR | 1.00 (Ref.) | 1.06 (0.76–1.46) | 1.03 (0.72–1.46) |
| Colorectal cancer | |||
| Cases/person-years | 175/330,969 | 44/57,622 | 62/71,330 |
| Age-adjusted HR | 1.00 (Ref.) | 1.02 (0.73–1.42) | 0.96 (0.71–1.29) |
| Multivariable HR | 1.00 (Ref.) | 1.18 (0.84–1.67) | 1.42 (1.02–2.00) |
| Lung cancer | |||
| Cases/person-years | 158/331,726 | 43/57,693 | 76/71,526 |
| Age-adjusted HR | 1.00 (Ref.) | 0.99 (0.71–1.39) | 1.09 (0.82–1.45) |
| Multivariable HR | 1.00 (Ref.) | 1.19 (0.84–1.68) | 1.10 (0.80–1.51) |
Multivariable model adjusted for age, BMI in 1995, menopausal hormone use, smoking status, educational attainment, geographic region, and family history of breast cancer.