Table 3.
Bilateral oophorectomy relative to hysterectomy alone and risk of incident cancer in the Black Women's Health Study, 1995–2011
| All ages at surgery |
Age at surgery <40 years |
Age at surgery ≥40 years |
||||
|---|---|---|---|---|---|---|
| Hysterectomy alone | With bilateral oophorectomy | Hysterectomy alone | With bilateral oophorectomy | Hysterectomy alone | With bilateral oophorectomy | |
| ER+ breast cancer | ||||||
| Cases/person-years | 96/56,079 | 88/69,740 | 42/33,051 | 27/29,595 | 54/23,027 | 61/40,146 |
| Age-adjusted HR | 1.00 (Ref.) | 0.64 (0.48–0.87) | 1.00 (Ref.) | 0.70 (0.43–1.14) | 1.00 (Ref.) | 0.56 (0.38–0.81) |
| Multivariable HR | 1.00 (Ref.) | 0.62 (0.45–0.85) | 1.00 (Ref.) | 0.67 (0.39–1.15) | 1.00 (Ref.) | 0.51 (0.34–0.77) |
| ER– breast cancer | ||||||
| Cases/person-years | 48/56,037 | 60/69,705 | 27/33,039 | 23/29,583 | 21/22,998 | 37/40,122 |
| Age-adjusted HR | 1.00 (Ref.) | 0.93 (0.63–1.37) | 1.00 (Ref.) | 0.87 (0.49–1.53) | 1.00 (Ref.) | 0.89 (0.51–1.55) |
| Multivariable HR | 1.00 (Ref.) | 1.03 (0.67–1.59) | 1.00 (Ref.) | 1.00 (0.53–1.90) | 1.00 (Ref.) | 0.95 (0.51–1.76) |
| Colorectal cancer | ||||||
| Cases/person-years | 44/57,622 | 62/71,330 | 19/33,748 | 23/30,152 | 25/23,875 | 39/41,178 |
| Age-adjusted HR | 1.00 (Ref.) | 0.96 (0.65–1.42) | 1.00 (Ref.) | 1.19 (0.64–2.22) | 1.00 (Ref.) | 0.77 (0.46–1.28) |
| Multivariable HR | 1.00 (Ref.) | 1.31 (0.85–2.00) | 1.00 (Ref.) | 1.63 (0.82–3.24) | 1.00 (Ref.) | 1.07 (0.61–1.88) |
| Lung cancer | ||||||
| Cases/person-years | 43/57,693 | 76/71,526 | 19/33,790 | 27/30,225 | 24/23,903 | 49/23,903 |
| Age-adjusted HR | 1.00 (Ref.) | 1.10 (0.76–1.61) | 1.00 (Ref.) | 1.35 (0.75–2.46) | 1.00 (Ref.) | 0.94 (0.57–1.55) |
| Multivariable HR | 1.00 (Ref.) | 0.97 (0.65–1.45) | 1.00 (Ref.) | 1.22 (0.63–2.36) | 1.00 (Ref.) | 0.79 (0.47–1.33) |
| Women with 0-<2 years of menopausal hormone use | ||||||
| ER+ breast cancer | ||||||
| Cases/person-years | 60/40,303 | 19/22,306 | 27/23,697 | 5/9,474 | 33/16,606 | 14/12,832 |
| Age-adjusted HR | 1.00 (Ref.) | 0.50 (0.30–0.86) | 1.00 (Ref.) | 0.42 (0.16–1.12) | 1.00 (Ref.) | 0.49 (0.25–0.94) |
| Multivariable HR | 1.00 (Ref.) | 0.52 (0.30–-0.90) | 1.00 (Ref.) | 0.43 (0.16–1.18) | 1.00 (Ref.) | 0.50 (0.26–0.99) |
| ER– breast cancer | ||||||
| Cases/person-years | 30/40,277 | 22/22,304 | 17/23,687 | 8/9,474 | 13/16,590 | 14/12,829 |
| Age-adjusted HR | 1.00 (Ref.) | 1.26 (0.71–2.24) | 1.00 (Ref.) | 1.22 (0.51–2.94) | 1.00 (Ref.) | 1.24 (0.57–2.74) |
| Multivariable HR | 1.00 (Ref.) | 1.25 (0.70–2.23) | 1.00 (Ref.) | 1.19 (0.49–2.88) | 1.00 (Ref.) | 1.11 (0.48–2.53) |
| Colorectal cancer | ||||||
| Cases/person-years | 35/41,332 | 33/22,886 | 15/24,121 | 13/9,633 | 20/17,212 | 20/13,252 |
| Age-adjusted HR | 1.00 (Ref.) | 1.26 (0.77–2.08) | 1.00 (Ref.) | 1.57 (0.71–3.46) | 1.00 (Ref.) | 0.96 (0.50–1.85) |
| Multivariable HR | 1.00 (Ref.) | 1.28 (0.77–2.14) | 1.00 (Ref.) | 1.65 (0.73–3.73) | 1.00 (Ref.) | 0.98 (0.49–1.93) |
| Lung cancer | ||||||
| Cases/person-years | 25/41,350 | 33/22,994 | 11/24,151 | 11/9,668 | 14/17,198 | 22/13,325 |
| Age-adjusted HR | 1.00 (Ref.) | 1.50 (0.88–2.57) | 1.00 (Ref.) | 1.61 (0.68–3.80) | 1.00 (Ref.) | 1.37 (0.68–2.77) |
| Multivariable HR | 1.00 (Ref.) | 1.26 (0.72–2.20) | 1.00 (Ref.) | 1.71 (0.68–4.31) | 1.00 (Ref.) | 1.10 (0.52–2.32) |
Multivariable model adjusted for age, BMI in 1995, menopausal hormone use, smoking status, educational attainment, geographic region, and family history of breast cancer.