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. 2015 May 26;6(3):e00565-15. doi: 10.1128/mBio.00565-15

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Copyright © 2015 Herbert et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 1 — NPC1 knockout mice are protected from mouse-adapted EBOV infection. Npc1^−/− (n = 28), Npc1^+/− (n = 21), and wild-type littermate control (n = 19) mice were challenged i.p. with 100 PFU of mouse-adapted EBOV. Mice were monitored for weight loss (A) and mortality (B) following challenge. On days 3 (C) and 7 (D) postchallenge, subsets of mice from each group were euthanized and viral titers were determined for the indicated tissues by plaque assay. The dotted line indicates the assay limit of detection. ****, P ≤ 0.0001 compared to wild-type mice.