FIG 5 .

Imipramine reduces EBOV replication in vivo. Wild-type mice were challenged i.p. with 100 PFU of mouse-adapted EBOV and treated either sid (n = 39) or qod (n = 30) with 20 mg/kg of imipramine. Control mice (n = 40) received an equivalent volume of vehicle control sid. Mice were monitored for weight loss (A) and mortality (B) following challenge. On days 3 (C) and 5 (D) postchallenge, subsets of mice from control and qod groups were euthanized, and viral titers were determined for the indicated tissues by plaque assay. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001.