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. 2015 May 26;6(3):e00638-15. doi: 10.1128/mBio.00638-15

TABLE 1 .

Quantitation of infiltrating cells in the lungs of TRIF−/− and C57BL/6J mice following SARS-CoV infectiona

Cell category No. of cells (×104)
Day 4
 Day 6
Mock
 SARS
 Mock
 SARS
WT TRIF−/− WT TRIF−/− WT TRIF−/− WT TRIF−/−
Total 1,430 1,490 13,100 16,500 813 1,620 7,240 7,880
    Neutrophil 54.6 49.9 272 892* 35.4 45.8 44.5 252
    Monocyte 91.4 111 1,860 2,470 85.8 110 1,360 877
    Ly6Chi Mono 11.0 24.3 250 1,070* 47.9 27.9 394 276
    Ly6Clo Mono 80.8 87.6 1,620 1,430 28.9 63.5 951 466*
    Alveolar Mac 66.1 80.5 178 338 34.0 59.4 119 229*
    pDC 1.27 4.86 13.2 18.7 4.74 5.92 5.81 36.4***
Viable lymphocyte 1,080 1,080 10,800 10,800 586 1,110 5,950 5,000
    Total T cells 180 287 1,930 1,800 120 294 1,910 972*
    CD4+ T cells 67.6 108 689 625 51.4 159 693 476
    CD8+ T cells 71.2 119 622 642 52.4 118 1,000 398**
a

Flow cytometry was used to measure cell populations in the lungs of mice; numbers indicate mean counts of cells from lungs. Numbers in bold indicate TRIF−/− mice infected with SARS-CoV whose results were significantly different from those determined for wild-type (WT) mice infected with SARS-CoV (*, P < 0.05; **, P < 0.01; ***, P < 0.001 [by Student’s unpaired t test]). There were no significant differences between TRIF−/− mice and wild-type mice in the numbers of cells from mock-inoculated mice.