Fig 3. The effect of simvastatin treatment on the expression of muscle atrophy-related genes, Atrogin-1, MuRF1 and Myostatin.
Rats were treated with vehicle (Control) or simvastatin at 60 (Sim 60) and 80 mg.kg-1.day-1 (Sim 80) for 14 days. Muscle mRNA is extracted and analyzed as described in the Methods. mRNA expression was normalised to total cDNA. *—significantly different from Control. Mean ± SEM. n = 6–8/group. One way ANOVA with Newman-Keul’s post-hoc test. P < 0.05.