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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Neuromuscul Dis. 2015;2(1):39–49. doi: 10.3233/JND-140062

Figure 4. Diaphragm fibrosis associates with fibrosis in the heart.

Figure 4

A) Diaphragm fibrosis correlated positively with LV fibrosis using Spearman based methods, further supporting the concept that scarring in the respiratory muscles may predict scarring in the LV. B) Interestingly, diaphragm fibrosis correlated negatively with RV fibrosis, indicating that the diaphragm correlation with LV fibrosis is independent of RV pathology. C) Scatter plot representing abdominal and diaphragm fibrosis for each animal. Although abdominal fibrosis correlates negatively with diaphragm fibrosis, the distribution suggests a more complex relationship between the two organs. Specifically, there are very few animals with high level abdominal and diaphragm fibrosis (intersection point). Rather, the cohort can be divided into two virtual populations: those that preferentially developed diaphragm fibrosis with little abdominal fibrosis, and those that preferentially developed abdominal fibrosis with little diaphragm fibrosis. D) Frequency distribution of fibrosis found within the diaphragm of the full cohort.