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. Author manuscript; available in PMC: 2015 May 28.
Published in final edited form as: Nature. 2015 Feb 25;519(7541):57–62. doi: 10.1038/nature14228

Figure 1. Persistent gp130 activation causes aberrant IEC proliferation and differentiation.

Figure 1

(a) Wild-type (WT) and villin-gp130Act (Tg) small intestine lengths at 3 months (n=5). Data represent averages ± SEM. *P < 0.05. (b) Hematoxylin and eosin (H&E) staining of paraffin-embedded small intestinal sections from WT and Tg mice. Shown are representative images. (c, e–g) Immunohistochemical (IHC) analysis of paraffin-embedded small intestinal sections from WT and Tg mice (n=6). Ki67 and BrdU incorporation (c), Alcian blue (AB)+MMP7 and chromogranin A (ChrA) (e), Wheat germ agglutinin (WGA) (f), and alkaline phosphatase (AP) and DAPI (g) stainings. (d) Ki67 and BrdU positive cells were counted in each crypt. Data are averages ± SD. *P < 0.05. Scale bars represent 100 μm (b, c, e–g).