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. Author manuscript; available in PMC: 2015 May 28.
Published in final edited form as: Nature. 2015 Feb 25;519(7541):57–62. doi: 10.1038/nature14228

Figure 2. gp130 activates YAP and Notch signaling.

Figure 2

(a) Lysates of WT and Tg jejuna were analyzed for expression and phosphorylation of the indicated proteins. (b) P-STAT3, YAP and HES1 stainings of paraffin-embedded small intestinal sections (n=6). Positive cells were enumerated in each villus or crypt. Data are averages ± SD. *P < 0.05. (c, d) WT and Tg small intestinal organoids stained with YAP (c) and CD44 C-terminal (d) antibodies were examined by immunofluorescent (IF) microscopy. Scale bars represent 100 μm (b–d) and all data are representative of at least 2-3 independent experiments.