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. Author manuscript; available in PMC: 2015 May 28.
Published in final edited form as: Nature. 2015 Feb 25;519(7541):57–62. doi: 10.1038/nature14228

Extended Data Figure 4. Aberrant intestinal differentiation in gp130Act mice depends on Notch and YAP but not on STAT3.

Extended Data Figure 4

(a) MMP7 staining of paraffin-embedded sections of control and DBZ-treated (10 μmol/kg) villin-gp130Act small intestines. Positive cells were enumerated in each crypt (n=3). Data represent averages ± SD. *P < 0.05. (b) MMP7 and lysozyme staining of paraffin-embedded sections of villin-gp130Act and villin-gp130Act/YapΔIEC small intestines. Positive cells were enumerated in each crypt (n=4). Data represent averages ± SD. *P < 0.05. (c) PAS, Ki67, YAP, P-STAT3, HES1 and MMP7 staining of paraffin-embedded sections of villin-gp130Act and villin-gp130Act/Stat3ΔIEC small intestines. Positive cells were enumerated in each villus or crypt (n=4). Data represent averages ± SD. *P < 0.05. Scale bars represent 100 μm (a–c) and all data are representative of at least 2–3 independent experiments.