Extended Data Table 1.
Elevated P-Src and YAP expression in colonic biopsies from CD patients
Shown are the results from P-Src and YAP IHC analyses, some of whose images are shown in Fig. 4d. Patient characteristics are included.
| Healthy Control | CD patient | |
|---|---|---|
| DN or SP | 11 | 7 |
| DP | 0 | 11 |
| P<0.05 |
| Characteristics of Controls and Patients with Crohn’s Disease | ||
|---|---|---|
|
| ||
| Crohn’s disease N = 18 |
Controls N = 11 |
|
|
| ||
| Age (years +/− S.D.) | 53.0 +/− 12.2 | 39.6 +/− 13.2 |
|
| ||
| Disease duration (years +/− S.D.) | 14.7 +/− 13.1 | NA |
|
| ||
| Disease phenotype | ||
| Ileocolonic disease | 72% | NA |
| Colonic disease | 28% | |
|
| ||
| TNF antagonist use | 17% | 0% |
|
| ||
| Immune modulator use(azathioprine, 6-mercaptopurine) | 17% | 0% |
|
| ||
| 5-Aminosalicylate use | 56% | 0% |
|
| ||
| Steroid use | 5% | 0% |
|
| ||
| Histopathology | ||
| Active chronic colitis | 78% | 0% |
| Inactive chronic colitis | 22% | 0% |
DN or SP: Double negative (DN) staining for P-Src and YAP or single positive (SP) staining of either P-Src or YAP.
DP: Double positive (DP) staining for both P-Src and YAP.
N = number of patients, S.D. = standard deviation, Na = not applicable