Abbreviations used: A, acidic region; ABD, actin binding domain; AD, ankyrin domain; B, basic region; C, cofilin homology domain; DD, dimerizing domain; E, effector region; EGFR, epidermal growth factor receptor domain; FBR, F-actin binding region; FERM, band 4.1/ERM domain; GBD, GTPase-binding domain; Ig, immunoglobulin-like domain; LR, linker region; PR, proline-rich domain; PTB, phosphotyrosine binding domain; S, spectrin-related domain; SAM-PNT, sterile α motif/pointed domain; SH3, Src homology 3 domain; V, verprolin homology domain; WH1, WASP homology domain.