Table 1. The Kyoto encyclopedia of genes and genome-based (KEGG) pathway enrichment assay of differentially expressed genes between astrocytes from adult geckos, embryonic rats, and adult rats.
| KEGG pathway | Gene counts | |
|---|---|---|
| Metabolism | 20 | |
| Propanoate metabolism | 8 | |
| Inositol phosphate metabolism | 12 | |
| Environmental Information Processing | 117 | |
| Wnt signaling pathway | 28 | |
| Hedgehog signaling pathway | 11 | |
| TGF-beta signaling pathway | 17 | |
| Phosphatidylinositol signaling system | 17 | |
| ECM-receptor interaction | 19 | |
| Cell adhesion molecules (CAMs) | 25 | |
| Cellular Processes | 94 | |
| Focal adhesion | 36 | |
| Adherens junction | 17 | |
| Tight junction | 26 | |
| Gap junction | 15 | |
| Organismal Systems | 97 | |
| Leukocyte transendothelial migration | 28 | |
| Vascular smooth muscle contraction | 21 | |
| Aldosterone-regulated sodium reabsorption | 9 | |
| Long-term depression | 13 | |
| Axon guidance | 26 | |
| Human Diseases | 184 | |
| Pathways in cancer | 57 | |
| Colorectal cancer | 15 | |
| Glioma | 12 | |
| Melanoma | 14 | |
| Small cell lung cancer | 15 | |
| Non-small cell lung cancer | 12 | |
| Hypertrophic cardiomyopathy (HCM) | 19 | |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 21 | |
| Dilated cardiomyopathy (DCM) | 19 | |
Differentially expressed genes (DEGs) between astrocytes from adult and embryonic rats were identified first. Among these DEGs, 1585 genes were further investigated for higher or lower expression levels (more than 2 folds) in astrocytes from adult and embryonic rats, as well as astrocytes from adult geckos. The table shows the most frequently involved pathway of these 1585 genes (determined by the KEGG analysis). Italicized bold pathways belong to the top five most frequent involved pathways.