Table 2. Clusters with significant changes in DTI indices of white matter microstructure after sleep deprivation (TP2 compared with TP3).

DTI parameter	No. of voxels in cluster	Change after sleep deprivation	MNI (x, y, z) maxima	Anatomical region of the peak voxel a	Peak voxel P-value
FA	30337	↓	21, −41, 27	R Splenium*	0.003
AD	7680	↓	17, −4, 5	R PLIC	0.021
	2676	↓	−1, 29, 8	Fmin	0.029
	551	↓	−20, 11, −23	L Orbitofrontal*	0.043
	12	↓	10, −22, 7	R ATR	0.049
	7	↓	−17, 36, 18	L Cingulum, Fmin	0.049
	4	↓	19, 28, 35	R Superior frontal gyrus*	0.049

DTI; diffusion tensor imaging. TP; time point. MNI; Montreal Neurological Institute. R; right. L; left. PLIC; posterior limb of internal capsule. Fmin; forceps minor. ATR; anterior thalamic radiation.

^aAnatomical region based on Johns Hopkins University (JHU) white matter tractography atlas and the ICBM-DTI-81 white matter labels atlas [36–38].

*Not within the white matter atlases; gross anatomical description.