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. 2015 May 28;10(5):e0128445. doi: 10.1371/journal.pone.0128445

Fig 4. ROS scavenger Trolox attenuates ROS production and caspase 3/7 activation in ketamine-treated neurons.

Fig 4

To determine whether ROS production mediates activation of caspase 3/7, iPSC-derived dopaminergic neurons were treated for 6 h with ketamine with or without the ROS scavenger, Trolox. (A) Trolox (500 μM) significantly inhibited ROS generation in the 500 μM ketamine-treated neurons (1.24-fold ± 0.14 ketamine alone vs. 1.01-fold ± 0.06 ketamine with Trolox). (B) Trolox also inhibited caspase 3/7 activation in the 500 μM ketamine-treated neurons (1.43-fold ± 0.12 ketamine alone vs. 1.05-fold ± 0.19 ketamine with Trolox). Results are presented as mean ± SD; n = 4 for each experiment. ** P < 0.01, compared with untreated controls.