Table 10.1.
Karyopherin alpha paralogs in different organisms
| Homo sapiens | Mus musculus | Drosophila melanogaster | Saccharomyces cerevisiae | |||||
|---|---|---|---|---|---|---|---|---|
| Subtype | Gene name | Importin designation |
Gene name |
Importin designation |
Gene name | Importin designation |
Gene name |
Importin designation |
| S | KPNA1 | alpha5 | Kpna1 | alpha1 | Kap-alpha1 | alpha1 | Srp1 | Kap60 |
| KPNA5 | alpha6 | – | – | – | – | – | – | |
| KPNA6 | alpha7 | Kpna6 | alpha6 | – | – | – | – | |
| P | KPNA2 | alpha1 | Kpna2 | alpha2 | Pen | alpha2 | – | – |
| KPNA7 | alpha7 | Kpna7a | alpha7a | – | – | – | – | |
| Q | KPNA3 | alpha4 | Kpna3 | alpha3 | – | – | – | – |
| KPNA4 | alpha3 | Kpna4 | alpha4 | Kap-alpha3 | alpha3 | – | – | |
KPNA family members are categorized into three subtypes, S, P, and Q based on amino acid sequence homology.
Saccharomyces cerevisiae has a single karyopherin (SRP1), while Homo sapiens, Mus musculus, and Drosophila melanogaster each contain multiple karyopherin paralogs. The gene name and importin alpha designation are given for each species to clarify confusion regarding karyopherin/importin designations between species. A dash (–) indicates the absence of a karyopherin homologue in that species.
a
Placement of recently discovered murine KPNA7 into subtype P is tentative.