TABLE 3.
Trait association with interaction between PPARG2 and HNF4A among BetaGene subjects
|
PPARG2 Pro12Ala genotype
|
Interaction P value
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Ala/Pro or Ala/Ala
|
Pro/Pro
|
|||||||
|
HNF4A rs2144908 genotype
| ||||||||
| A/A | A/G | G/G | A/A | A/G | G/G | Additive* | Recessive* | |
| n | 30 | 44 | 23 | 102 | 190 | 84 | ||
| BMI (kg/m2) | 26.3 (0.7) | 27.4 (0.8) | 27.8 (0.9) | 27.8 (1.0) | 27.8 (1.0) | 27.9 (1.1) | 1 | 1 |
| Fasting glucose (mmol/l) | 5.1 (0.2) | 5.1 (0.3) | 5.0 (0.2) | 5.1 (0.2) | 5.1 (0.2) | 5.1 (0.2) | 1 | 1 |
| 2-h glucose (mmol/l) | 6.3 (0.6) | 7.0 (0.9) | 7.0 (0.8) | 7.0 (0.8) | 7.1 (0.8) | 7.0 (0.8) | 1 | 1 |
| Fasting insulin (pmol/l) | 36 (15) | 57 (46) | 79 (77) | 53 (28) | 59 (42) | 54 (32) | 0.636 | 0.294 |
| 2-h insulin (pmol/l) | 279 (93) | 467 (212) | 625 (292) | 405 (142) | 413 (179) | 383 (155) | 0.054 | 0.039 |
| 30′ Δinsulin (pmol/l) | 334 (59) | 432 (98) | 588 (173) | 406 (93) | 412 (111) | 396 (118) | 0.222 | 0.021 |
| SG (×10−2 min−1) | 1.79 (0.18) | 1.56 (0.22) | 1.47 (0.21) | 1.69 (0.19) | 1.62 (0.21) | 1.59 (0.20) | 1 | 1 |
| SI (×10−3 min−1 per pmol/l) | 3.92 (0.88) | 2.73 (0.92) | 1.95 (0.72) | 2.74 (0.73) | 2.71 (0.85) | 2.89 (0.85) | 0.0011 | 0.0006 |
| AIR (pmol/l × 10 min) | 4,480 (921) | 5,198 (1,353) | 6,832 (2,707) | 5,230 (1,410) | 5,060 (1,538) | 4,567 (1,534) | 0.969 | 1 |
| Disposition index | 16,113 (2,686) | 13,026 (3,152) | 12,426 (2,829) | 13,561 (2,882) | 12,742 (2,805) | 12,257 (2,899) | 1 | 1 |
Genotype-specific trait values are shown as mean (SD) adjusted for age, sex, and BMI (except in the case of BMI). The interaction P value is Bonferroni-corrected for 30 tests, as described in RESEARCH DESIGN AND METHODS.
*
Genetic model assumed for HNF4A rs2144908 in the interaction with PPARG2. PPARG2 Pro12Ala was assumed to follow a dominant genetic model for Ala.