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. Author manuscript; available in PMC: 2015 May 28.
Published in final edited form as: Diabetes. 2007 Dec 27;57(4):1048–1056. doi: 10.2337/db07-0848

TABLE 3.

Trait association with interaction between PPARG2 and HNF4A among BetaGene subjects

PPARG2 Pro12Ala genotype
Interaction P value
Ala/Pro or Ala/Ala
Pro/Pro
HNF4A rs2144908 genotype
A/A A/G G/G A/A A/G G/G Additive* Recessive*
n 30 44 23 102 190 84
BMI (kg/m2) 26.3 (0.7) 27.4 (0.8) 27.8 (0.9) 27.8 (1.0) 27.8 (1.0) 27.9 (1.1) 1 1
Fasting glucose (mmol/l) 5.1 (0.2) 5.1 (0.3) 5.0 (0.2) 5.1 (0.2) 5.1 (0.2) 5.1 (0.2) 1 1
2-h glucose (mmol/l) 6.3 (0.6) 7.0 (0.9) 7.0 (0.8) 7.0 (0.8) 7.1 (0.8) 7.0 (0.8) 1 1
Fasting insulin (pmol/l) 36 (15) 57 (46) 79 (77) 53 (28) 59 (42) 54 (32) 0.636 0.294
2-h insulin (pmol/l) 279 (93) 467 (212) 625 (292) 405 (142) 413 (179) 383 (155) 0.054 0.039
30′ Δinsulin (pmol/l) 334 (59) 432 (98) 588 (173) 406 (93) 412 (111) 396 (118) 0.222 0.021
SG (×10−2 min−1) 1.79 (0.18) 1.56 (0.22) 1.47 (0.21) 1.69 (0.19) 1.62 (0.21) 1.59 (0.20) 1 1
SI (×10−3 min−1 per pmol/l) 3.92 (0.88) 2.73 (0.92) 1.95 (0.72) 2.74 (0.73) 2.71 (0.85) 2.89 (0.85) 0.0011 0.0006
AIR (pmol/l × 10 min) 4,480 (921) 5,198 (1,353) 6,832 (2,707) 5,230 (1,410) 5,060 (1,538) 4,567 (1,534) 0.969 1
Disposition index 16,113 (2,686) 13,026 (3,152) 12,426 (2,829) 13,561 (2,882) 12,742 (2,805) 12,257 (2,899) 1 1

Genotype-specific trait values are shown as mean (SD) adjusted for age, sex, and BMI (except in the case of BMI). The interaction P value is Bonferroni-corrected for 30 tests, as described in RESEARCH DESIGN AND METHODS.

*

Genetic model assumed for HNF4A rs2144908 in the interaction with PPARG2. PPARG2 Pro12Ala was assumed to follow a dominant genetic model for Ala.