TABLE 4.
SI association with interaction between PPARG2 and HNF4A among IRASFS subjects
|
PPARG2 Pro12Ala genotype
|
Interaction P value
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Ala/Pro or Ala/Ala
|
Pro/Pro
|
|||||||
|
HNF4A rs2144908 genotype
| ||||||||
| A/A | A/G | G/G | A/A | A/G | G/G | Additive* | Recessive* | |
| San Antonio | ||||||||
| n | 32 3.65 (1.94) |
63 3.15 (1.57) |
23 2.45 (1.33) |
75 2.71 (1.43) |
187 2.58 (1.21) |
104 2.42 (1.45) |
0.056 | 0.018 |
| San Luis Valley | ||||||||
| n | 19 3.18 (1.69) |
44 3.74 (1.74) |
25 3.99 (2.04) |
85 3.22 (1.58) |
214 3.30 (1.69) |
109 3.26 (1.73) |
0.401 | 0.176 |
Genotype-specific trait values are shown as mean (SD) adjusted for age, sex, and BMI.
*
Genetic model assumed for HNF4A rs2144908 in the interaction with PPARG2. PPARG2 Pro12Ala was assumed to follow a dominant genetic model for Ala.