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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: J Cell Physiol. 2015 Sep;230(9):2142–2151. doi: 10.1002/jcp.24943

Figure 5. Working model showing how TPO directly stimulates OC progenitor cells while indirectly stimulating OB proliferation through MKs.

Figure 5

MKs also elaborate unidentified soluble factor(s) which are likely to inhibit OC formation. The enhancement in OB lineage cell number by MKs also increases overall RANKL expression and subsequent activation of OCs.