Table 3.

Clinical pathologic characteristics by presence of hippocampal sclerosis and TDP-43 pathology

	Hippocampal Sclerosis
	Not present			Present
	TDP-43 absent n=308	TDP-43 present n=245	p-value	TDP-43 absent n=12	TDP-43 present n=71	p-value
Age at death, y, mean (SD)	87.2, 6.9	89.5, 5.9	< 0.001	88.2, 7.4	91.4, 5.7	0.085
Female, n (%)	190, 65.3	180, 68.7	0.395	9, 75.0	52, 73.2	0.898
Education, mean (SD)	16.1, 3.7	16.0, 3.4	0.843	16.3, 4.5	16.0, 3.5	0.797
MMSE, mean (SD)	22.6, 8.1	19.9, 9.6	< 0.001	22.6, 8.6	12.3, 9.7	< 0.001
No Cognitive Impairment	116, 40.6	63, 28.1	0.009	2, 18.1	5, 7.5	0.011
Mild Cognitive Impairment	82, 28.7	67, 29.9		4, 36.4	6, 9.0
Probable AD	88, 30.8	94, 42.0		5, 45.5	56, 83.6
NIA-Reagan, score 1-2, n (%)	148, 52.9	178,67.9	< 0.001	7, 58.3	59, 83.1	0.063
Macroinfarcts, n (%)	96, 33.0	103, 39.3	0.122	5, 41.7	30, 42.3	0.970
Microinfarcts, n (%)	80, 27.5	71, 27.1	0.918	6, 50.0	23, 32.4	0.327
Arteriolosclerosis, n (%)	208, 71.7	212, 81.5	0.007	8, 66.7	59, 83.1	0.233
Atherosclerosis, n (%)	239, 82.4	236, 90.1	0.010	9, 75.0	61, 85.9	0.390
Lewy bodies, n (%)	60, 20.6	57, 21.8	0.744	1, 8.3	26, 36.6	0.092

Chi-square or Fisher exact test as appropriate