Table 1.

Attributes and levels of side effects

Attribute	Level of severity
	Mild/Low	Moderate/Medium	Severe/High
Hair loss	None/not noticeable	--	Obvious
Fatigue	None/full activity	I often need a nap to reset myself	Major impact on my activity level
Nausea	None/easy to ignore	Manageable with medication/still eating	Can’t eat
Pain	None/easy to ignore	Manageable with OTC medication (eg, Advil, Tylenol)	Need prescription-strength medication
Diarrhea	2 stools or less/day	3+ loose stools per day	Unable to leave the house due to frequency and urgency of diarrhea
Risk of infection	None/modest	--	Hospitalized due to infection
Tingling in hands and feet	None/easy to ignore	Bothersome but manageable	Interferes with activities of daily living (eg, getting dressed)
Out-of-pocket cost	$500	$1,000	$3,000

Key: OTC – over-the-counter.