Table 3.
Average value to patient of a reduction in side effects
| Attribute | Levels | Value to patient | Average value to patient | Importance |
|---|---|---|---|---|
| Hair loss | None/not noticeable | 0.5374 | 0.5374 | 6 |
| Obvious | -0.5374 | |||
| Fatigue | None/full activity | 0.6941 | 0.5628 | 5 |
| I often need a nap to reset myself | 0.1501 | |||
| Major impact on my activity level | -0.8841 | |||
| Nausea | None/easy to ignore | 0.7060 | 0.7709 | 3 |
| Manageable with OTC medication (eg, Advil, Tylenol) | 0.0854 | |||
| Need prescription-strength medication | -0.4654 | |||
| Diarrhea | 2 stools or less per day | 0.9371 | 0.8809 | 2 |
| 3+ loose stools per day | 0.3842 | |||
| Unable to leave the house due to frequency and urgency of diarrhea | -1.3213 | |||
| Risk of infection | None/modest | 1.090 | 1.090 | 1 |
| Hospitalized due to infection | -1.090 | |||
| Tingling in hands and feet | None/easy to ignore | 0.6693 | 0.6624 | 4 |
| Bothersome, but manageable | 0.2643 | |||
| Interferes with daily activities (eg, getting dressed) | -0.9336 |
The average value to patients is the part-worth utility calculated using effects coding. The relative importance of each attribute was determined based on the range of each attribute’s utility values.