Table 1.
Unadjusted mRNA expression and protein levels of candidate markers between groups
| High-risk vs. control offspring | High-risk early vs. later clinical stage | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control n = 16 | High-risk n = 19 | p valuea | Early n = 12 | Later n = 7 | p valueb | ||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||||
| BDNF | mRNA | 0.1753 | (0.2616) | 0.2737 | (0.3525) | 0.5410 | 0.3464 | (0.4403) | 0.1593 | (0.0635) | 0.7346 |
| Protein | 105.13 | (68.85) | 234.83 | (162.69) | 0.0056 | 290.96 | (152.59) | 138.60 | (140.03) | 0.0453 | |
| TNF | mRNA | 0.2290 | (0.2615) | 0.4759 | (0.8113) | 0.2485 | 0.6521 | (1.012) | 0.1991 | (0.1089) | 0.4747 |
| Protein | 55.53 | (20.07) | 54.33 | (12.28) | 0.8292 | 56.22 | (12.46) | 51.09 | (12.16) | 0.3951 | |
| IFN | mRNA | 0.0388 | (0.0688) | 0.0615 | (0.0658) | 0.0803 | 0.0584 | (0.0795) | 0.0663 | (0.0410) | 0.2447 |
| Protein | 81.56 | (26.80) | 70.99 | (28.70) | 0.2715 | 63.36 | (18.93) | 84.09 | (38.70) | 0.1324 | |
| IL-6 | mRNA | 0.0740 | (0.1063) | 0.0966 | (0.1956) | 0.8091 | 0.0846 | (0.2014) | 0.1156 | (0.2005) | 0.3192 |
| Protein | 5.98 | (1.62) | 7.77 | (3.18) | 0.0505 | 8.84 | (3.60) | 5.92 | (0.59) | 0.0502 | |
| IL-10 | mRNA | 0.0549 | (0.0521) | 0.0836 | (0.0779) | 0.7390 | 0.0683 | (0.0620) | 0.1076 | (0.0984) | 0.7219 |
| Protein | 16.16 | (8.82) | 19.36 | (6.04) | 0.2132 | 19.11 | (5.79) | 19.78 | (6.90) | 0.8243 | |
mRNA means and SD are presented as fold-change; protein levels are measured in picograms per microgram. a p value for t test comparing HR to control; mRNA is log-transformed; b p value for t test comparing early stage to late stage; mRNA is log-transformed.