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. 2014 Dec 10;3:721. doi: 10.1186/2193-1801-3-721

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© Shibahara et al.; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Histologic spectrum of SALL4-immunopositive hepatocellular carcinoma (HCC). (a) Poorly differentiated HCC with amphophylic cytoplasms. Hematoxylin and eosin (H&E) stain (bar, 100 μm). (b) Poorly differentiated HCC with clear cytoplasms and intracytoplasmic hyaline droplets. H&E stain (bar, 100 μm). (c) Poorly differentiated HCC with small, undifferentiated cells. H&E stain (bar, 100 μm). (d) Moderately differentiated HCC with ductile-like structures. H&E stain (bar, 100 μm). (e) Infiltrative HCC with thin-trabecular growth pattern. Extramedullary hematopoiesis is seen. H&E stain (left bar, 1 mm; right bar, 100 μm). (f) Well differentiated HCC with thin-trabecular architecture and vacuolated cytoplasm. H&E stain (bar, 100 μm).