Table 3.
Histologic characteristics of SALL4-immunopositive hepatocellular carcinoma
| SALL4(+) HCC (n=47) | SALL4(−) HCC (n=290) | P value | |
|---|---|---|---|
| Size (mm, mean±SD) | 58.3±35.8 | 52.2±38.7 | 0.312 |
| Grade (well/mod/por) | 1/19/27 | 47/192/51 | <0.001 |
| Vascular invasiona (present/absent) | 34/13 | 157/133 | 0.019 |
| Invasion to major vesselb (present/absent) | 5/42 | 17/273 | 0.209 |
| Bile duct invasion (present/absent) | 2/45 | 16/274 | 1.000 |
| Intrahepatic metastasis (present/absent) | 16/31 | 56/234 | 0.022 |
| Cytokeratin 19 (positive/negative) | 20/27 | 34/256 | <0.001 |
| EpCAM (positive/negative) | 24/23 | 24/266 | <0.001 |
SALL4, sal-like protein 4; HCC, hepatocellular carcinoma; SD, standerd deviation; well, well differentiated; mod, moderately differentiated; por, poorly differentiated; EpCAM, epithelial cell adhesion molecule.
Significant P-values are indicated in bold.
aMicrovascular and macrovascular invasion.
bInvasion to major branch of the portal and hepatic veins.