Table 4.
Prognostic factors of disease-free survival of hepatocellular carcinoma
| Short term (<1year) disease-free survival | Disease free survival | |||||||
|---|---|---|---|---|---|---|---|---|
| Factor | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (> 65 years vs. 0–65 years) | 0.920 (0.638–1.326) | 0.655 | 1.013 (0.773–1.330) | 0.923 | ||||
| Sex (female vs. male) | 0.969 (0.623–1.509) | 0.890 | 0.989 (0.717–1.364) | 0.947 | ||||
| HBV (positive vs. negative) | 1.241 (0.811–1.899) | 0.319 | 0.929 (0.666–1.295) | 0.663 | ||||
| HCV (positive vs. negative) | 1.079 (0.748–1.556) | 0.686 | 1.148 (0.875–1.505) | 0.320 | ||||
| Child-Pugh (B vs. A) | 1.310 (0.773–2.221) | 0.316 | 1.413 (0.960–2.080) | 0.079 | ||||
| AFP (>20 ng/ml vs. 0–20 ng/ml) | 1.843 (1.272–2.670) | 0.001 | 1.272 (0.834–1.939) | 0.264 | 1.195 (0.914–1.564) | 0.193 | ||
| Tumor size (>5 cm vs. 0–5 cm) | 3.253 (2.229–4.746) | <0.001 | 1.776 (1.165–2.708) | 0.008 | 2.095 (1.599–2.746) | <0.001 | 1.626 (1.186–2.228) | 0.003 |
| Histologic grade (por vs. well/mod) | 2.220 (1.510–3.265) | <0.001 | 1.165 (0.741–1.831) | 0.508 | 1.298 (0.943-1.786) | 0.110 | ||
| Vascular invasion (present vs. absent) | 4.465 (2.805–7.108) | <0.001 | 2.180 (1.279–3.714) | 0.004 | 1.907 (1.443–2.519) | <0.001 | 1.156 (0.832–1.607) | 0.387 |
| Intrahepatic metastasis (present vs. absent) | 4.730 (3.264–6.854) | <0.001 | 2.593 (1.689–3.981) | <0.001 | 3.989 (2.956–5.384) | <0.001 | 2.885 (2.030–4.099) | <0.001 |
| Background liver (LC vs. non-LC) | 1.124 (0.774–1.632) | 0.540 | 1.357 (1.032–1.786) | 0.029 | 1.496 (1.120-1.999) | 0.006 | ||
| SALL4 (positive vs. negative) | 1.746 (1.088–2.801) | 0.021 | 0.843 (0.457–1.554) | 0.584 | 1.185 (0.801–1.753) | 0.396 | ||
| Cytokeratin 19 (positive vs. negative) | 2.650 (1.746-4.002) | <0.001 | 1.832 (1.145-2.931) | 0.012 | 1.662 (1.165–2.371) | 0.005 | 1.606 (1.100–2.345) | 0.014 |
| EpCAM (positive vs. negative) | 1.976 (1.260–3.097) | 0.003 | 1.330 (0.794-2.230) | 0.279 | 1.503 (1.037–2.180) | 0.031 | 1.133 (0.768-1.672) | 0.529 |
HR, hazard ratio; CI, confidence interval; HBV, hepatitis B virus; HCV, hepatitis C virus; AFP, alpha-fetoprotein; por, poorly differentiated; well, well differentiated; mod, moderately differentiated; LC, liver cirrhosis; SALL4, sal-like protein 4; EpCAM, epithelial cell adhesion molecule.
Significant P-values are indicated in bold.