. 2014 Nov 1;70(6):771–778. doi: 10.1093/gerona/glu189

Table 3.

Association Between eGFR and Odds of Cognitive Impairment

	Odds Ratio of Cognitive Impairment (95% CI)
	Unadjusted Model	p Value	Base Model*	p Value	MV Model^†	p Value
eGFR_CysC ^‡ quartiles, mL/min/1.73 m²
Q4 (76.1–109.4)	1.08 (0.82–1.41)	.580	1.13 (0.85–1.49)	.403	1.18 (0.88–1.58)	.276
Q2–Q3 (55.6–76.0)	1.00 (Referent)		1.00 (Referent)		1.00 (Referent)
Q1 (21.8–55.5)	1.42 (1.09, 1.85)	.010	1.37 (1.05–1.80)	.022	1.26 (0.94–1.67)	.117
eGFR_Cr+CysC ^§ quartiles, mL/min/1.73 m²
Q4 (81.2–116.4)	1.24 (0.95–1.62)	.121	1.25 (0.94–1.66)	.124	1.35 (1.01–1.82)	.046
Q2–Q3 (61.9–81.1)	1.00 (Referent)		1.00 (Referent)		1.00 (Referent)
Q1 (23.5–61.8)	1.45 (1.11–1.90)	.007	1.36 (1.03–1.79)	.029	1.29 (0.97–1.71)	.080
eGFR_Cr ^\|\| quartiles, mL/min/1.73 m²
Q4 (86.1–115.1)	1.15 (0.88–1.50)	.317	1.27 (0.95–1.69)	.106	1.32 (0.98–1.77)	.068
Q2–Q3 (66.5–86.0)	1.00 (Referent)		1.00 (Referent)		1.00 (Referent)
Q1 (21.6–66.4)	1.13 (0.86–1.48)	.368	1.13 (0.86–1.49)	.379	1.09 (0.82–1.45)	.535

Notes: eGFR = estimated glomerular filtration rate.

*Adjusted for age and race.

^†Adjusted for multiple covariates, including age, race, education, self-reported health status, Geriatric Depression Scale, Instrumental Activities of Daily Living, smoking, alcohol intake, body mass index, history of coronary vascular disease, history of diabetes, history of hypertension, and history of stroke.

^‡Calculated by the CKD-EPI cystatin C equation (27).

^§Calculated by the CKD-EPI creatinine–cystatin C equation (27).

^||Calculated by the CKD-EPI creatinine equation (27).