Table 6.
Adverse Events in Pregnant Women Reported to the Vaccine Adverse Event Reporting System Following Measles, Mumps, and Rubella Vaccine (n = 134a), 1 January 2003–31 July 2013
| Adverse Events | MMR Vaccine Alone, No. (%) | MMR With Other Vaccines, No. (%) | All MMR Vaccines, No. (%) |
|---|---|---|---|
| Total No. of pregnancy AE reports | 44 | 90 | 134 |
| Pregnancy-specific AEs | |||
| Spontaneous abortion | 3 (6.8) | 14 (15.6) | 17 (12.7) |
| Therapeutic abortion | 2 (4.5) | 3 (3.3) | 5 (3.7) |
| Oligohydramniosb | 3 (6.8) | 2 (2.2) | 5 (3.7) |
| Vaginal bleeding/ spotting | 0 (0.0) | 3 (3.3) | 3 (2.2) |
| Preterm deliveryc | 0 (0.0) | 2 (2.2) | 2 (1.5) |
| Prolonged rupture of membranes | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Postpartum hemorrhaged | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Hyperemesis | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Preeclampsia | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Placenta previa | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Total | 8 (18.2) | 29 (32.2) | 37 (27.6) |
| Nonpregnancy specific AEs | |||
| Rash | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Urinary tract infection | 1 (2.3) | 0 (0.0) | 1 (0.7) |
| Upper respiratory infection | 1 (2.3) | 0 (0.0) | 1 (0.7) |
| Headache and stomach ache | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Fever | 1 (2.3) | 0 (0.0) | 1 (0.7) |
| Influenza infection | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Pain at injection site | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Total | 3 (6.8) | 4 (4.4) | 7 (5.2) |
| Congenital abnormalities/major birth defects | |||
| Jacobsen syndromee | 1 (2.3) | 0 (0.0) | 1 (0.7) |
| Anorectal disorderf | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Triploidy 69XYg | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Turner syndromef | 1 (2.3) | 0 (0.0) | 1 (0.7) |
| Unspecified congenital anomaliesg | 1 (2.3) | 0 (0.0) | 1 (0.7) |
| Total | 3 (6.8) | 2 (2.2) | 5 (3.7) |
| Fetal/infant outcomes | |||
| Neonatal jaundice | 1 (2.3) | 0 (0.0) | 1 (0.7) |
| Meningitis at 3 wk of ageg | 0 (0.0) | 1 (1.1) | 1 (0.7) |
| Total | 1 (2.3) | 1 (1.1) | 2 (1.5) |
| No AE (or no information) | 29 (65.9) | 54 (60.0) | 83 (61.9) |
Abbreviations: AE, adverse event; MMR, measles, mumps, and rubella.
a Includes 134 AEs in 131 reports; 3 pregnancy reports contained 2 AEs each (AE in mother and AE in infant).
b One patient with oligohydramnios also had gestational hypertension, another had group B streptococcal infection.
c Patient also had a rash and elevated liver function tests after vaccination.
d Patient also had gestational diabetes.
e Maternal vaccination in the fourth week of gestation.
f Maternal vaccination in the first week of gestation.
g Maternal vaccination in the second week of gestation.