Table 4.
Gene-based associations of endothelial system genes with BP changes and hypertension
| Genea | SBP | DBP | Hypertension incidence |
|---|---|---|---|
| EDN2 | 0.2374 | 0.2192 | 0.3168 |
| DDAH1 | <1.00×10−6* | 0.1039 | 0.4708 |
| VCAM1 | 0.3064 | 0.3686 | 0.2400 |
| SELP | 0.0082 | 0.3682 | 0.3728 |
| SELE | 0.0174 | <1.00×10−6*,** | <1.00×10−6*,*** |
| EDNRA | 0.7230 | 0.5602 | 2.39×10−4* |
| MEF2C | 0.2894 | 0.3497 | 0.7273 |
| EDN1 | 0.6833 | 0.1868 | 0.6838 |
| SERPINE1 | 0.1812 | 0.2668 | 0.3338 |
| NOS3 | 0.0473 | 0.1719 | 0.1999 |
| VWF | 0.6362 | 0.8390 | 0.2935 |
| EDNRB | 0.2124 | 0.5420 | 0.3558 |
| COL18A1 | 4.00×10−6* | 0.0251 | 0.1166 |
Abbreviations: BP, blood pressure; DBP, diastolic blood pressure; SBP, systolic blood pressure; SNP, single-nucleotide polymorphism.
a CYBA and TGFB1 genes are not included since they only have one tag-SNP each.
*Significant after adjustment for multiple testing.
**Significant after excluding SNP rs3917436 that was significant in single-marker analyses (P = 6.30×10−4).
***Significant after excluding the 3 SNPs that were significant in single-marker analyses (P = 1.80×10−4).