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Signaling cascades, as outlined by our two recent papers (Li et al., 2009, 2011). (A–C) Membrane-proximal signaling evoked by DEP-organics (DEP-OE) leading to Ca++ influx via TRPV4 and (D) activation of RAS (by Ca++) and subsequent MAP-kinase signaling that leads to MMP-1 activation. (A color image is available in the online version.)
