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. 2015 Mar 26;125(22):3377–3387. doi: 10.1182/blood-2015-01-620278

Figure 7.

Figure 7

Model of miR-24-mediated regulation of VWF biosynthesis and secretion through the aldose reductase pathway. Hyperglycemia upregulates aldose reductase activity and increases ROS generation in endothelial cells. Increased ROS upregulates c-Myc/c-Myc phosphorylation, which downregulates miR-24, leading to increased expression of VWF, Furin, and HRH1. Therefore, the expression of VWF itself, Furin-dependent VWF maturation, and the histamine-regulated secretion pathways are coordinately upregulated with hyperglycemia.