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. Author manuscript; available in PMC: 2015 May 29.
Published in final edited form as: Brain Behav Immun. 2013 Jun 28;33:112–122. doi: 10.1016/j.bbi.2013.06.004

Figure 1.

Figure 1

Mechanical allodynia is induced by CCI surgery. A single spinal (intrathecal, IT) administration of an A2AR agonist (ATL313) reduces neuropathic pain. (A) An A1R agonist (CCPA) transiently reverses neuropathic pain induced by CCI, lasting less than 72 h compared to vehicle controls. An A1R agonist has no effect on sham-operated rats. **P<0.05 at each time point for CCI+10 pmol CCPA compared to CCI+vehicle, *P<0.05 for CCI+1 pmol CCPA compared to CCI+vehicle; n=4-6 rats /group. (B) An A2BR agonist (BAY606583) administered at equimolar doses to ATL313 results in comparable reversal of CCI-induced neuropathic allodynia lasting 4 wk. There was no effect of the A2BR agonist on sham-operated rats. *P<0.01 CCI+1 pmol BAY606583 compared to CCI+vehicle, **P<0.01 CCI+10 pmol BAY606583 compared to CCI+vehicle; n=5-6 rats/group.