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. Author manuscript; available in PMC: 2015 May 29.
Published in final edited form as: Brain Behav Immun. 2013 Jun 28;33:112–122. doi: 10.1016/j.bbi.2013.06.004

Figure 3.

Figure 3

An A2AR agonist downregulates TNFα in central immune cells. (A) TNFα release (pg/ml) from neonatal cortical microglia and (B) astrocytes incubated for 24 h with LPS is attenuated by co-administration of ATL313. n=3/4 wells/group and the experiment was replicated at least twice. *P<0.05, ** P<0.01. *** P<0.001 compared to LPS+vehicle. IL-10 release (pg/ml) from neonatal cortical microglia (C) and astrocytes (D) incubated for 24 h with LPS is upregulated and maintained by ATL313 but not upregulated by co-administration of ATL313. *P<0.05, ** P<0.01. *** P<0.001 compared to LPS+vehicle. n=3/4 wells/group and the experiment was replicated at least twice.