Figure 3.

The ropB polymorphisms and decreased secreted streptococcal cysteine protease B (SpeB) are significantly associated with pharyngitis. A, Univariate analysis of the association between ropB alleles (wild type [solid bar] or variant [hatched bar]) and type of group A streptococci (GAS) infection (invasive [dark green bar] or oropharyngeal [light green bar]) is shown. B, Univariate analysis of the association between SpeB expression (SpeB expressed [solid bar] or absent [hatched bar]) and type of GAS infection (invasive [dark green bar] or oropharyngeal [light green bar]) is shown. Odds ratio (OR), probability (P), and confidence interval (CI) are shown for univariate analyses of all 1178 invasive and pharyngitis strains studied, only the Ontario invasive and pharyngitis strains, all strains except the frequently identified SpeB-positive V7I strains, and all strains except those from the Alberta collection.