Figure 4.

Neuronal fiber depletion in the retina of Tg-MYOC^Y437H/+/Sod2^+/− mice. (A) Immunofluorescence of 10-month-old whole-mounted retinas stained with antibodies against NFH, which label RGC axons. Crossed arrows indicate the directions of the corresponding poles of the retinas. Four sets of littermate retinas were stained. Representative images are shown. Scale bar, 1 mm. (B) Relative fluorescence intensities of the NFH-staining of the entire whole-mounted retinas as in (A). All values are presented as mean ± SE. **P < 0.01. n shows the number of analyzed mice. (C) Higher magnification images of the dorsal retinas in (A) are shown from the central region (bottom) to the peripheral region (top).