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. 2015 Mar 3;24(12):3322–3334. doi: 10.1093/hmg/ddv082

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Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 7. — Degeneration in the optic nerves of Tg-MYOC^Y437H/+/Sod2^+/− mice. Representative electron micrographs of the optic nerve cross-sections from 10-month-old littermates are shown. Red asterisks indicate the loss of axonal profiles in the edges of the optic nerve that were instead filled up with low-density material. Right panels show the higher magnification images for the areas marked by the red dotted line in the images from Tg-MYOC^Y437H/+ and Tg-MYOC^Y437H/+/Sod2^+/− mice. Degenerating axons in the higher magnification image of Tg-MYOC^Y437H/+/Sod2^+/− optic nerve were identified by the lack of myelin sheath (black asterisks) and the presence of amorphous axoplasm, axolemma detachment, myelin debris or double myelination (red arrows). Scale bars, 2 μm.