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. Author manuscript; available in PMC: 2015 May 29.
Published in final edited form as: J Invest Dermatol. 2014 Apr 2;134(8):2192–2201. doi: 10.1038/jid.2014.165

Figure 2. HBD-2 expression and secretion is increased in fetal KC.

Figure 2

Fetal, neonatal and adult KC were cultured for 24 h in the presence or absence of IL-1α or the TLR5L flagellin and the concentration of HBD-2 in cell lysates (a) and supernatants (b) was determined by ELISA. Basal HBD-2 levels (NS) were significantly higher in supernatants and cell lysates from fetal KC as compared to neonatal and adult KC (#p<0.05). Stimulation with IL-1α or TLR5L induced HBD-2 expression in all KC groups (*p<0.05, **p<0.005). The mean and SEM of two to six independent experiments for each group are depicted; NS: non-stimulated control;