Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure and biosynthesis of representative capuramycin-type inhibitors of TL1. A, the CarU and α-d-mannopyranuronate components are found in all capuramycin-type antibiotics. SQ641 and SQ922 are semisynthetic leads prepared from 2b and 1c, respectively. B, prior results from isotopic enrichment studies using the indicated 13C-labeled precursors. The numerical value represents the -fold enrichment at the indicated site relative to a reference carbon.
