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. 2015 Apr 14;290(22):13812–13829. doi: 10.1074/jbc.M115.653261

FIGURE 9.

FIGURE 9.

miR-96-182-183 cluster expression is elevated in metastatic breast tumors. A, heat map shows the expression profile of miRNAs and BRMS1L by qRT-PCR. B, expression of miRNAs and BRMS1L was detected by qRT-PCR in benign and malignant breast tissues. C, expression of miRNAs was examined by in situ hybridization, and expression of hGH, GHR, and BRMS1L was detected by IHC in formalin-fixed paraffin-embedded breast cancer specimens and normal mammary specimens. Magnification was ×400. D, quantification of miRNAs and hGH, GHR, and BRMS1L levels in formalin-fixed paraffin-embedded breast cancer specimens and normal mammary specimens. The values represent the average percentage of DAB-positive cells. E, schematic representation reveals the signaling pathway of the miR-96-182-183 cluster involved in regulation of breast cancer EMT and invasion. n.s., not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001 (Student's t test). Error bars, S.E.