TABLE II.

Paired comparisons of regional 5-HT_1AR binding potential (BP) values (mean±SD) derived using simplified reference tissue modeling in the pre- versus post-treatment conditions.

	Entire Sample (n=15)			SSRI alone (n=10)			Venlafaxine +/− SSRI (n=5)
ROI	Pre-treatment	Post-treatment	W; p-valueb	Pre-treatment	Post-treatment	W; p-valueb	Pre-treatment	Post-treatment	W; p-valueb
MTCa	5.62 ± 1.37	5.14 ± 1.39	−0.85;0.43	5.59 ± 1.63	5.11 ± 1.51	−0.53;0.65	5.68 ± 0.90	5.19 ± 1.29	−0.67;0.63
RN	2.02 ± 0.40	1.92 ± 0.44	−0.97;0.36	2.05 ± 0.47	2.02 ± 0.45	−0.36;0.77	1.94 ± 0.24	1.73 ± 0.40	−1.21;0.31
LLO	3.44 ± 0.51	3.50 ± 0.71	−0.28;0.80	3.35 ± 0.55	3.38 ± 0.73	−0.15;0.92	3.61 ± 0.43	3.74 ± 0.67	−0.67;0.63
RLO	3.51 ± 0.48	3.53 ± 0.65	−0.06;0.98	3.42 ± 0.52	3.54 ± 0.71	−0.46;0.70	3.69 ± 0.37	3.51 ± 0.59	−0.94;0.44
OCC-PC	2.02 ± 0.40	2.11 ± 0.57	−1.08;0.30	2.08 ± 0.35	2.13 ± 0.50	−0.46;0.70	1.91 ± 0.52	2.10 ± 0.77	−0.94;0.44
PCG	2.77 ± 0.59	2.90 ± 0.68	−0.85;0.42	2.54 ± 0.41	2.74 ± 0.66	−0.87;0.43	3.23 ± 0.67	3.23 ± 0.64	−0.14;1.00

Abbreviations: ROI=region of interest; MTC=mesiotemporal cortex; RN=raphe nucleus; LLO=left lateral orbital cortex; RLO=right lateral orbital cortex; OCC-PC =occipital cortex-posterior cingulate gyrus; PCG=post central gyrus.

^aone subject’s MTC-BP data were excluded because the model failed to provide stable curve fits for this region’s time-activity concentrations.

^bW=Wilcoxon signed ranks test statistic.