TABLE III.

Mean regional [¹¹C]WAY distribution volume (DV) and binding potential (BP) values in depressed subjects, pre and post-treatment derived using compartmental modeling (CMOD) and arterial input functions [mean ± SD; paired data, n=6].

ROI	CMOD DV			CMOD BP
	Pre-treatment	Post-treatment	W; p-value	Pre-treatment	Post-treatment	W; p-value
CER	0.44 ± 0.12	0.51 ± 0.11	−0.73;0.56	n.a.	n.a.	n.a.
MTCa	7.50 ± 2.98	6.81 ± 1.95	−0.73;0.63	15.67 ± 2.74	11.36 ± 4.21	−1.46;0.25
RN	2.03 ± 0.68	2.11 ± 0.50	−0.11;1.00	3.68 ± 1.62	3.21 ± 1.09	−0.52;0.69
LLO	2.86 ± 0.85	3.14 ± 0.88	−0.52;0.69	5.47 ± 1.40	5.17 ± 1.34	−0.73;0.56
RLO	2.78 ± 0.74	3.11 ± 0.53	−0.1.15;0.31	5.41 ± 1.59	5.21 ± 1.28	−0.31;0.84
OCC-PC	1.79 ± 0.60	2.00 ± 0.50	−0.94; 0.44	3.06 ± 1.20	2.95 ± 0.78	−0.31;0.84
PCG	2.29 ± 0.69	2.60 ± 0.49	−0.94;0.44	4.17 ± 0.96	4.17 ± 1.01	−0.11;1.00

^atwo subjects’s MTC-BP data were excluded because the model failed to provide stable curve fits for this region’s time-activity concentrations.

Abbreviations as in table II