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. 2015 May 29;5:10679. doi: 10.1038/srep10679

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Copyright © 2015, Macmillan Publishers Limited

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In interphase cells, Rif1 is associated with chromosomes. When chromosome condensation takes place at the onset of mitosis, Rif1 dissociates from chromosomes and reassociates at the late anaphase stage. We propose that at this stage it interacts with PP1 via the SILK-RVxF motif and recruits PP1 to the chromosomes. This recruitment leads to dephosphorylation of substrates on the chromosome and decondensation of chromosomes. PP1 and Rif1 probably disassociate at this stage. The association and dissociation of Rif1 from chromosomes may be mediated by modifications of Rif1protein.