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. 2015 May 19;42(5):903–915. doi: 10.1016/j.immuni.2015.04.012

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Absence of Integrin β8 on Treg Cells Exacerbates Intestinal and Peripheral Inflammatory T Cell Responses in Lymphocyte-Replete Mice

(A–C) Control (Itgb8^WT/flfoxp3^YFP-Cre) and Itgb8 Treg cell KO (Itgb8^fl/flfoxp3^YFP-Cre) mice received 1% DSS in drinking water for 9 days.

(A) Percentage of initial weight from time of treatment. Error bars represent SEM.

(B and C) Percentage CD4⁺ T cell populations from the LILP (B) and H&E staining of colon samples (C) at day 9 post-treatment. Data (n = 5) are representative of two independent experiments.

(D–F) Control mice (Itgb8^fl/fl or Itgb8^WT/flfoxp3^YFP-Cre) and mice lacking Itgb8 expression in Treg cells (Itgb8^fl/flfoxp3^YFP-Cre) were immunized with ovalbumin/CFA followed by subcutaneous challenge with PBS in the left ear pinna and ovalbumin in the right.

(D and E) Mean ear thickness (D) and H&E staining of ears (E) 48 hr after challenge.

(F) Intracellular IFN-γ expression in CD4⁺ and CD8⁺ T cells from ear draining lymph node. Total cell number and representative flow cytometry plots of data are displayed. Data (n = 6–7) are from two independent experiments.